Chronic Unpredictable Stress Drives Non-pathological, Adaptive Metabolic Hormone Reprogramming with Reduced Insulin Resistance Linked to Depressive-like Behaviors
Yueyang Luo, Tangcong Chen, Mengdie Li, Marta Kubera, Yingqian Zhang, Yulan Huang, Michael Maes
This study shows chronic unpredictable stress causes adaptive metabolic hormone changes in mice, linked to reduced insulin resistance and depressive-like behaviors, without metabolic disease.
bioRxiv · Feb 7, 2026 · PreprintNeuroscience