Michael H. J. Maes

Molecular Mimicry Between Epstein-Barr Virus and Human Herpesvirus-6 Proteins and Central Nervous System Proteins: Implications for T and B Cell Immunogenicity in an In Silico Study.

This study identifies shared pentapeptides between EBV and HHV-6 antigens and CNS proteins, suggesting molecular mimicry may trigger autoimmune responses via T and B cell activation.

Chronic Unpredictable Stress Drives Non-pathological, Adaptive Metabolic Hormone Reprogramming with Reduced Insulin Resistance Linked to Depressive-like Behaviors

This study shows chronic unpredictable stress causes adaptive metabolic hormone changes in mice, linked to reduced insulin resistance and depressive-like behaviors, without metabolic disease.

FTO (fat-mass and obesity-associated protein) deficiency aggravates age-dependent depression-like behaviors and cognitive impairment

This study shows that FTO deficiency worsens age-related depression-like behaviors and cognitive impairment in mice by impairing hippocampal synaptic plasticity.

Regulatory T and activated T cells in the chronic unpredictable mild stress mice: sex differences and effects of treatments

This study examines the effects of antidepressants on immune responses and depressive behaviors in male and female CUMS mice, finding sex differences in T-cell activation and immune regulation.

Paranoid schizophrenia and methamphetamine-induced paranoia are both characterized by a similar LINE-1 partial methylation profile, which is more pronounced in paranoid schizophrenia.

The paper compares LINE-1 methylation patterns in paranoid schizophrenia and methamphetamine-induced paranoia, finding distinct partial methylation profiles with higher mCuC in schizophrenia.

Supervised machine learning to decipher the complex associations between neuro-immune biomarkers and quality of life in schizophrenia

This study uses machine learning to identify predictors of health-related quality of life in schizophrenia, finding that neuro-immune biomarkers and cognitive impairments significantly impact HR-QoL.

Early Life Trauma Predicts Affective Phenomenology and the Effects are Partly Mediated by Staging Coupled with Lowered Lipid-Associated Antioxidant Defences.

This study finds that early life trauma is linked to increased risk of mood and anxiety disorders and more severe affective symptoms, partly mediated by staging and lowered antioxidant defenses.

A new schizophrenia model: immune activation is associated with induction of thetryptophan catabolite pathway and increased eotaxin levels which together determinememory impairments and schizophrenia symptom dimensions.

This paper investigates how immune activation and tryptophan catabolite pathway activity contribute to memory impairments and schizophrenia symptom dimensions.