Tangcong Chen

Chronic Unpredictable Stress Drives Non-pathological, Adaptive Metabolic Hormone Reprogramming with Reduced Insulin Resistance Linked to Depressive-like Behaviors

This study shows chronic unpredictable stress causes adaptive metabolic hormone changes in mice, linked to reduced insulin resistance and depressive-like behaviors, without metabolic disease.

FTO (fat-mass and obesity-associated protein) deficiency aggravates age-dependent depression-like behaviors and cognitive impairment

This study shows that FTO deficiency worsens age-related depression-like behaviors and cognitive impairment in mice by impairing hippocampal synaptic plasticity.

Regulatory T and activated T cells in the chronic unpredictable mild stress mice: sex differences and effects of treatments

This study examines the effects of antidepressants on immune responses and depressive behaviors in male and female CUMS mice, finding sex differences in T-cell activation and immune regulation.