The CPEB ortholog Orb2 regulates brain size through the TRIM-NHL RNA-binding protein, Brain tumor
Taylor Hailstock, Joseph Buehler, Beverly V. Robinson, Timothy C.H. Low, Yuqing Hua, Temitope H. Adebambo, Jack A. Govaerts, Todd Andrew Schoborg, Howard D. Lipshitz, Dorothy A. Lerit
This study identifies Orb2 as a regulator of brain size in Drosophila by modulating Brain tumor protein levels through its RNA-binding and poly-Q domains.
bioRxiv · Jul 18, 2025 · PreprintDevelopmental Biology