Howard D. Lipshitz

This study shows that Pumilio and Brain tumor regulate Smaug mRNA degradation during the Drosophila maternal-to-zygotic transition, preventing ectopic Smaug protein expression and ensuring proper mRNA clearance.

The paper generates a high-resolution proteogenomic atlas of human neuronal development using long-read RNA sequencing and proteomics, revealing novel isoforms and their role in neurodevelopmental risk mechanisms.

Switch-TRIBE profiles RNA-protein interactions in Drosophila neural stem cells, identifying cell-type specific targets and revealing regulatory strategies of RBPs in neurogenesis.

This study shows that RNA-binding is essential for Brat function in Drosophila development by generating and testing RNA-binding defective mutant alleles.

This study identifies ORB2 as a regulator of maternal mRNAs during the Drosophila MZT, showing its ZZ domain mediates repression through interactions with post-transcriptional regulators.

This paper shows that the C-terminal ZZ domain of Drosophila ORB2 is essential for spermatid individualization, as its deletion leads to mislocalization of key proteins and sterility.

This study identifies Orb2 as a regulator of brain size in Drosophila by modulating Brain tumor protein levels through its RNA-binding and poly-Q domains.

The paper identifies Usp5 as a key interactor of Brat that facilitates pre-complex assembly for mRNA degradation during differentiation in Drosophila.

The paper identifies Smaug's role in repressing osk and bru1 mRNAs to regulate germ plasm synthesis and PGC number in Drosophila embryos.

This study identifies novel Pumilio target genes and reveals how Pumilio and CCR4-NOT deadenylase regulate mRNA stability and translation efficiency in Drosophila.

BrainRBPedia is a database of 1072 RNA-binding proteins linked to neurodevelopmental disorders, with a machine learning model prioritizing RBPs for autism and intellectual disability.

The paper shows that precise degradation of post-transcriptional repressors during the Drosophila MZT is essential for orderly transition to zygotic gene control.

This study identifies RIN/G3BP-bound mRNAs in Drosophila and shows they are short, stable, and highly translated, suggesting RIN stabilizes and enhances their translation.