Timothy C.H. Low

The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc binding 'ZZ' domain

This study identifies ORB2 as a regulator of maternal mRNAs during the Drosophila MZT, showing its ZZ domain mediates repression through interactions with post-transcriptional regulators.

The C-terminal ZZ domain of the Drosophila ORB2 RNA-binding protein is required for spermatid individualization

This paper shows that the C-terminal ZZ domain of Drosophila ORB2 is essential for spermatid individualization, as its deletion leads to mislocalization of key proteins and sterility.

The CPEB ortholog Orb2 regulates brain size through the TRIM-NHL RNA-binding protein, Brain tumor

This study identifies Orb2 as a regulator of brain size in Drosophila by modulating Brain tumor protein levels through its RNA-binding and poly-Q domains.

Smaug regulates germ plasm synthesis and primordial germ cell number in Drosophila embryos by repressing the oskar and bruno 1 mRNAs

The paper identifies Smaug's role in repressing osk and bru1 mRNAs to regulate germ plasm synthesis and PGC number in Drosophila embryos.

Precise temporal regulation of post-transcriptional repressors is required for an orderly Drosophila maternal-to-zygotic transition

The paper shows that precise degradation of post-transcriptional repressors during the Drosophila MZT is essential for orderly transition to zygotic gene control.