Molecular basis of quorum-sensing signal transduction by CqsS and its inhibition by CqsA the autoinducer synthase
Mengchan Liu, Yufan Yang, Julie S. Valastyan, Yuru Zhang, Grace A. Beggs, Yanhong Liu, Zhenhua Wang, Bonnie L. Bassler, Hongwu Qian
This study determines the cryo-EM structures of CqsS and its interaction with CqsA and CAI-1, revealing the molecular mechanism of quorum-sensing signal transduction in Vibrio harveyi.
bioRxiv · May 6, 2026 · PreprintMicrobiology