Bonnie L. Bassler

This study shows how Vibrio cholerae pellicles form through planktonic cell recruitment mediated by extracellular matrix factors and quorum-sensing.

This paper identifies two pathways in phage VP882: quorum-sensing-driven lysis and stress-mediated host growth suppression, with QtiQ inactivating a complex that causes growth arrest.

A pectin-based formulation preserves milk fat globule membranes in stored human milk, reducing lipase-driven degradation and maintaining sensory quality.

The paper shows how prophages use quorum-sensing systems to compete with each other and the host, making lysis decisions based on autoinducer ratios.

This study investigates how Vibrio parahaemolyticus quorum sensing regulates phage VP882 transmission by controlling receptor accessibility and enabling superinfection.

The paper identifies a double-negative feedback loop between LuxT and VqmR in V. cholerae that regulates quorum-sensing genes and biofilm formation.

This study determines the cryo-EM structures of CqsS and its interaction with CqsA and CAI-1, revealing the molecular mechanism of quorum-sensing signal transduction in Vibrio harveyi.

This study identifies L-xylosone as a human metabolite that mimics the bacterial quorum-sensing autoinducer AI-2, revealing a new host-microbe interaction.

The paper identifies a family of temperate phages that detect a quorum-sensing autoinducer, DPO, across multiple bacterial species, expanding understanding of phage-bacterial communication.

The paper identifies food-derived compounds that extend the shelf-life of frozen human milk by preserving fat content and reducing rancid-associated free fatty acids.

This study uses smFISH to analyze gene expression in V. cholerae biofilms, revealing spatiotemporal patterns and the role of quorum sensing and c-di-GMP signaling in matrix gene expression.

This study identifies PqsR inhibitors that reveal RhlR's dependence on PqsE for pyocyanin biosynthesis, suggesting PqsR inhibition as a therapeutic strategy against Pseudomonas aeruginosa.

The paper identifies vca0646-0649 genes regulated by HapR that induce cell death in Vibrio cholerae independently of the T6SS system, revealing a second parallel cell death pathway.

This study shows that the LuxO-OpaR quorum-sensing cascade influences the lysis-lysogeny decision of phage VP882 based on host cell density and environment.