Safe focused ultrasound-mediated blood-brain barrier opening is driven primarily by transient reorganization of tight junctions
Rebecca Lynn Noel, Tara Kugelman, Maria Eleni Karakatsani, Sanjid Shahriar, Moshe J. Willner, Daniella Amanda Jimenez, Claire Sunha Choi, Yusuke Niimi, Robin Ji, Dritan Agalliu, Elisa E. Konofagou
This study investigates how focused ultrasound opens the blood-brain barrier at low and high pressures, finding that low pressures cause transient tight junction reorganization while high pressures lead to irreversible damage.
Communications Engineering · Feb 21, 2026Peer-reviewedBioengineering