Human TIMELESS, a potential circadian clock regulator, plays an essential role in survival and reawakening of metastasis-initiating cells in bone
Hirokazu Shimizu, Lei Wang, Masumi Tsuda, Reo Maruyama, Yusuke Saito, Kohei Kumegawa, Masato Takahashi, Rie Horii, Hiroaki Suzuki, Kenichi Watanabe, Ryuta Arai, Masaaki Murakami, Norimasa Iwasaki, Shinya Tanaka
This study identifies TIMELESS as a critical regulator of metastasis-initiating cell survival and reawakening in bone, with a metabolic inhibitor showing promise for therapeutic intervention.
bioRxiv · Mar 18, 2025 · PreprintCancer Biology