Reo Maruyama

Distal-less homeobox 5 gives rise to myofibroblastic carcinoma-associated fibroblasts to promote collective breast cancer invasion

This study identifies DLX5 as a key driver of myofibroblastic carcinoma-associated fibroblasts (myCAFs) in breast cancer, showing its role in promoting tumor invasion through TGF-β signaling.

Plasticity of extrachromosomal DNA segregation during drug adaptation

This study investigates how extrachromosomal DNA (ecDNA) copy numbers change during drug treatment, showing that resistant clones can actively reconfigure segregation behavior rather than relying on pre-existing clones.

A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

The paper shows that miR-195 can rescue B cell development in EBF1-deficient progenitor cells by enabling CD19 expression and recombination processes.

Breast cancer identity is defined by specialized enhancer sets via lysine deacetylation

The paper identifies hypoacetylation-defined enhancers in luminal breast cancer cells and links them to subtype-specific gene regulation and patient classification.

Clonal lineage tracing and parallel multiomics profiling reveal transcriptional diversification induced by ARID1A deficiency

This study uses an integrated platform to show that ARID1A deficiency increases transcriptomic and epigenetic heterogeneity in cancer cells through stochastic and constrained chromatin changes.

Human TIMELESS, a potential circadian clock regulator, plays an essential role in survival and reawakening of metastasis-initiating cells in bone

This study identifies TIMELESS as a critical regulator of metastasis-initiating cell survival and reawakening in bone, with a metabolic inhibitor showing promise for therapeutic intervention.

HERC2 promotes BLM and WRN to suppress G-quadruplex DNA

This study shows HERC2 promotes BLM and WRN to suppress G-quadruplex DNA, with E3 activity essential for this function and affecting cell sensitivity to G4 stabilizers.