Rabies virus antagonizes interferon signaling by targeting phosphorylated STAT1 tetramers
Miku Minami, Aoi Sugiyama, Shatabdi Chakraborty, Tomo Nomai, Cassandra T. David, Yuichiro Takekawa, Fei Yan, Yuta Iizuka, Karyn L. Wilde, Satomi Inaba‐Inoue, Nana Yabuno, Mika Hirose, Tomoyasu Aizawa, Mina Sasaki, Shunsuke Kita, , Toyoyuki Ose
This study reveals how rabies virus P protein inhibits interferon signaling by selectively binding to phosphorylated STAT1 tetramers, stabilizing them and preventing DNA binding.
bioRxiv · Jul 30, 2026 · PreprintMolecular Biology