Author

Toyoyuki Ose

Hokkaido UniversityORCID 0000-0002-2001-9388Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Aoi SugiyamaiD· 1 shared Atsushi MinamiiD· 1 shared Cassandra T. DavidiD· 1 shared Fei YaniD· 1 shared Gregory W. MoseleyiD· 1 shared Hao LiiD· 1 shared Hideaki OikawaiD· 1 shared Hiroshi ItouiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperMolecular Biology

Aoi SugiyamaORCID

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3 papers

Recent·Most cited

Rabies virus antagonizes interferon signaling by targeting phosphorylated STAT1 tetramers

Miku Minami, Aoi Sugiyama, Shatabdi Chakraborty, Tomo Nomai, Cassandra T. David, Yuichiro Takekawa, Fei Yan, Yuta Iizuka, Karyn L. Wilde, Satomi Inaba‐Inoue, Nana Yabuno, Mika Hirose, Tomoyasu Aizawa, Mina Sasaki, Shunsuke Kita, , Toyoyuki Ose

This study reveals how rabies virus P protein inhibits interferon signaling by selectively binding to phosphorylated STAT1 tetramers, stabilizing them and preventing DNA binding.

bioRxiv · Jul 30, 2026 · PreprintMolecular Biology

High-throughput prediction of protein-protein interactions uncovers hidden molecular networks in biosynthetic gene clusters

Yoshitaka Moriwaki, Taro Shiraishi, Yohei Katsuyama, Kenichi Matsuda, Jie Zhang, Toyoyuki Ose, Atsushi Minami, Hideaki Oikawa, Tomohisa Kuzuyama, Ryuichiro Ishitani, Tohru Terada

The paper predicts protein-protein interactions in biosynthetic gene clusters to uncover hidden molecular networks and functional enzyme complexes.

Computational and Structural Biotechnology Journal · Mar 1, 2026Peer-reviewedBioinformatics

Sld3CBD-Cdc45 structural insights into Cdc45 recruitment for CMG complex formation on DNA replication

Hao Li, Izumi Ishizaki, Koji Kato, Xiaomei Sun, Sachiko Muramatsu, Hiroshi Itou, Toyoyuki Ose, Hiroyuki Araki, Min Yao

The paper presents the structure of Sld3CBD-Cdc45 complex and reveals interactions and conformational changes involved in Cdc45 recruitment for CMG complex formation.

eLife · Sep 8, 2025Peer-reviewedMolecular Biology