Priming Epigenetic Landscape at Gene Promoters through Transcriptional Activation in Mammalian Germ Cells
Peilin Li, Tatsuya Fujisawa, Haruka Narita, Yuta Uneme, Masahide Seki, Mengwen Hu, Ryohei Narumi, Satoshi H. Namekawa, Shehroz S. Khan, James Davie, Yutaka Suzuki, Jun Adachi, Ahmed Bilal Ashraf, Azusa Inoue, Mikiko C. Siomi, Soichiro Yamanaka
The paper shows that in mouse male germ cells, promoter chromatin states are shaped by H3K4me3 density and H3K27me3 dynamics, influencing gene expression during development.
bioRxiv · Nov 24, 2024 · PreprintGenomics