A potent macrocyclic peptide binder enables effector-free crystallization of the GTPase RAB27A
Rita Petracca, Montse Tersa, Elena De Vita, Thomas Lanyon‐Hogg, Yuteng Wu, Anna Kukushkina, Rhodri M. L. Morgan, Ernesto Cota, Louise J. Walport, Edward W. Tate
The paper identifies a macrocyclic peptide binder, IMP2660, that disrupts RAB27A-effector interactions and enables crystallization of RAB27A without an effector, revealing its structural features.
bioRxiv · Oct 15, 2026 · PreprintBiochemistry