Rita Petracca

This paper introduces a photoactivated fluorescent probe, AbzSH, for selective alkene labelling in proteins and complex biological samples.

The paper identifies a macrocyclic peptide binder, IMP2660, that disrupts RAB27A-effector interactions and enables crystallization of RAB27A without an effector, revealing its structural features.

This paper develops the first cell-active covalent inhibitors of RAB27-effector interactions, showing enantioselectivity and improved potency over a previously reported toxic compound.