Author

Ernesto Cota

Imperial College LondonORCID 0000-0002-4690-0683Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Ernesto Cota1 paper

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Edward W. TateiD· 2 shared Elena De VitaiD· 2 shared Montse TersaiD· 2 shared Rhodri M. L. MorganiD· 2 shared Rita PetraccaiD· 2 shared Thomas Lanyon‐HoggiD· 2 shared Adam ThomasiD· 1 shared Alan ArmstrongiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersBiochemistry

Edward W. TateORCID

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2 papers

Recent·Most cited

A potent macrocyclic peptide binder enables effector-free crystallization of the GTPase RAB27A

Rita Petracca, Montse Tersa, Elena De Vita, Thomas Lanyon‐Hogg, Yuteng Wu, Anna Kukushkina, Rhodri M. L. Morgan, Ernesto Cota, Louise J. Walport, Edward W. Tate

The paper identifies a macrocyclic peptide binder, IMP2660, that disrupts RAB27A-effector interactions and enables crystallization of RAB27A without an effector, revealing its structural features.

bioRxiv · Oct 15, 2026 · PreprintBiochemistry

Discovery of stereoselective targeted covalent inhibitors of the RAB27-effector protein-protein interaction

Elena De Vita, Adam Thomas, Delia Brustur, Montse Tersa, Rita Petracca, Shradda Vadodaria, Deborah A. Briggs, Jack W. Houghton, Thomas Lanyon‐Hogg, Gregory B. Craven, Rhodri M. L. Morgan, Alan Armstrong, David J. Mann, Katharine M. Lodge, Alistair N. Hume, , Edward W. Tate

This paper develops the first cell-active covalent inhibitors of RAB27-effector interactions, showing enantioselectivity and improved potency over a previously reported toxic compound.

Journal of the American Chemical Society · Aug 3, 2026Peer-reviewedBiochemistry