Author
Queen Mary University of LondonORCID 0000-0003-4707-8342Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Rita Petracca, Montse Tersa, Elena De Vita…·Edward W. Tate
The paper identifies a macrocyclic peptide binder, IMP2660, that disrupts RAB27A-effector interactions and enables crystallization of RAB27A without an effector, revealing its structural features.
Elena De Vita, Adam Thomas, Delia Brustur…·Edward W. Tate
This paper develops the first cell-active covalent inhibitors of RAB27-effector interactions, showing enantioselectivity and improved potency over a previously reported toxic compound.
Rishi R. Shah, Elena De Vita, Preethi Soundarya Sathyamurthi…·Edward W. Tate
This study designs and optimizes covalent VHL-targeted sulfonyl fluoride PROTACs that degrade BRD4 and androgen receptor without linker optimization.