Dysregulated expanded endocannabinoid system as therapeutic targets of amyotrophic lateral sclerosis
Daisuke Ito, Madoka Iida, Yohei Iguchi, Atsushi Hashizume, Shinichiro Yamada, Yoshiyuki Kishimoto, Shota Komori, Teppei Shimamura, Yuto Takemoto, Masahiro Nakatochi, Tomohiro Akashi, Kunihiko Hinohara, Hyeon‐Cheol Lee, Jun‐ichi Niwa, Gen Sobue, , Masahisa Katsuno
The paper identifies dysregulated expanded endocannabinoid system metabolites in ALS and shows FAAH inhibition improves motor neuron degeneration in models.
bioRxiv · Jan 12, 2024 · PreprintNeuroscience