Gen Sobue

The paper uses human iPSC-derived motor neurons to study SBMA, identifying neuropeptides as therapeutic targets.

This study identifies the Aβ-HMGB1 complex as a pathogenic factor in advanced Alzheimer's disease, showing it causes neuronal damage and that targeting HMGB1 improves symptoms in mouse models.

This study shows that psychosocial stress alters feeding behavior patterns in mice through disruptions in the mesolimbic dopamine system, suggesting these patterns could serve as biomarkers for stress and neuropsychiatric disorders.

The paper identifies dysregulated expanded endocannabinoid system metabolites in ALS and shows FAAH inhibition improves motor neuron degeneration in models.

This study identifies a new susceptibility locus, PLA2G4C, for Multiple System Atrophy through a genome-wide association study and functional analysis of a risk variant.

The paper identifies a GGC repeat expansion in the NOTCH2NLC gene using long-read sequencing, linking it to neuronal intranuclear inclusion disease in both familial and sporadic cases.