Author

Yuxiang Lang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:protein design· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Per Jr GreiseniD· 3 shared Chenrui XuiD· 2 shared Longfei Cong· 2 shared Roger ShekiD· 2 shared Yi ZhouiD· 2 shared Yifan LiiD· 2 shared Brian M Richardson· 1 shared Freddy Garces· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBioengineering

Per Jr GreisenORCID

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3 papers

Recent·Most cited

De Novo Computational Design of VHH Nanobodies Against LGR5

Chenrui Xu, Yifan Li, Trang Nguyen, Yi Zhou, Longfei Cong, Tek-Hyung Lee, Yuxiang Lang, Roger Shek, Yi Li, Per Jr Greisen

This paper presents a computational pipeline for designing VHH nanobodies against LGR5 without structural templates, resulting in high-affinity, stable binders validated by cryo-EM.

bioRxiv · Dec 5, 2025 · PreprintBioengineering

AI-guided design of common light chains to enable manufacturable bispecific antibodies

Longfei Cong, Brian M Richardson, Yi Zhou, Tong Li, Roger Shek, Yuxiang Lang, Ziwei Pang, Freddy Garces, Jarrod B. French, Per Jr Greisen

This paper presents an AI framework to design common light chains for bispecific antibodies, reducing experimental screening and enabling production-ready antibodies for 7 out of 10 targets.

bioRxiv · Oct 11, 2025 · PreprintBioengineering

Benchmarking Inverse Folding Models for Antibody CDR Sequence Design

Yifan Li, Yuxiang Lang, Chenrui Xu, Yi Zhou, Ziwei Pang, Per Jr Greisen

This study benchmarks AI models for antibody CDR sequence design, finding that specialized models like AntiFold perform better in complex regions while general models struggle with antibody-specific nuances.

PLoS ONE · Jun 4, 2025Peer-reviewedBioengineering