Author

Chenrui Xu

ORCID 0000-0002-5605-728XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein design· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

Per Jr GreiseniD· 2 shared Yi ZhouiD· 2 shared Yifan LiiD· 2 shared Yuxiang Lang· 2 shared Longfei Cong· 1 shared Roger ShekiD· 1 shared Tek-Hyung LeeiD· 1 shared Trang Nguyen· 1 shared

Activity by Year

2025-2025 · peak 2/yr

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10 top collaborators · 40 mutual co-author links

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2 shared papersBioengineering

Per Jr GreisenORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintDec 5, 2025

De Novo Computational Design of VHH Nanobodies Against LGR5

Chenrui Xu, Yifan Li, Trang Nguyen…·Per Jr Greisen

This paper presents a computational pipeline for designing VHH nanobodies against LGR5 without structural templates, resulting in high-affinity, stable binders validated by cryo-EM.

DOI 10.64898/2025.12.02.691880

protein structuredeep learning

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BioengineeringPLoS ONEPeer-reviewedJun 4, 2025

Benchmarking Inverse Folding Models for Antibody CDR Sequence Design

Yifan Li, Yuxiang Lang, Chenrui Xu…·Per Jr Greisen

This study benchmarks AI models for antibody CDR sequence design, finding that specialized models like AntiFold perform better in complex regions while general models struggle with antibody-specific nuances.

6 citations

protein sequencedeep learning

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