hESCs-derived organoids achieve liver zonation by LSEC modulation
Yuying Zhang, Chenyan Huang, Lei Sun, Lyu Zhou, Yudi Niu, Kaini Liang, Bingjie Wu, Peng Zhao, Zhi-Qiang Liu, Xiaolin Zhou, Peng Zhang, Jianchen Wu, Jie Na, Yanan Du
This study creates zonated liver organoids using hESCs-derived hepatocytes and LSECs, showing that GLP-1RA targets LSECs to alleviate NAFLD.
Advanced Science · Apr 25, 2025Peer-reviewedBioengineering