Author

Yanan Du

Center for Life SciencesORCID 0000-0003-2627-9727Unclaimed ORCID profile · follow to get notified of new preprints

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Yanan Du1 paper

Biology Disciplines

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Bioengineering· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Guy M. GeniniD· 2 shared Kaini LiangiD· 2 shared Xi‐Qiao FengiD· 2 shared Xiangjun PengiD· 2 shared Yudi NiuiD· 2 shared Yuxuan HuangiD· 2 shared Bingjie WuiD· 1 shared Chen WangiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiophysics

Guy M. GeninORCID

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3 papers

Recent·Most cited

Critical Cell Spacing Drives Phase Transition in Matrix-Mediated Tissue Condensation

Xiangjun Peng, Yuxuan Huang, Wenyu Kong, Yanan Du, Elliot L. Elson, Xi‐Qiao Feng, Guy M. Genin

The paper models how critical cell spacing drives a phase transition in matrix-mediated tissue condensation through mechanical feedback.

Proceedings of the National Academy of Sciences · Oct 3, 2025Peer-reviewedBiophysics

Chemo-mechanotherapy of fibrosis: dynamic control of biological materials through tissue-architecture-dependent crosslink disruption

Wenyu Kong, Meiyue Song, Xiangjun Peng, Lu Bai, Jia’nan Zeng, Kaini Liang, Yuhong Jin, Jiaxin Wang, Xue Wang, Yuxuan Huang, Yudi Niu, Lyu Zhou, Xi‐Qiao Feng, Chen Wang, Guy M. Genin, , Yanan Du

This study shows that mechanical stretching can disrupt pathological crosslinks in fibrotic tissues, reversing fibrosis in mice when combined with pharmacological treatment.

bioRxiv · Sep 1, 2025 · PreprintBioengineering

hESCs-derived organoids achieve liver zonation by LSEC modulation

Yuying Zhang, Chenyan Huang, Lei Sun, Lyu Zhou, Yudi Niu, Kaini Liang, Bingjie Wu, Peng Zhao, Zhi-Qiang Liu, Xiaolin Zhou, Peng Zhang, Jianchen Wu, Jie Na, Yanan Du

This study creates zonated liver organoids using hESCs-derived hepatocytes and LSECs, showing that GLP-1RA targets LSECs to alleviate NAFLD.

Advanced Science · Apr 25, 2025Peer-reviewedBioengineering