Complex aneuploidy triggers autophagy and p53-mediated apoptosis and impairs the second lineage segregation in human preimplantation embryos
Marius Regin, Yingnan Lei, Edouard Couvreu de Deckersberg, Charlotte Janssens, Anfien Huyghebaert, Yves Guns, Pieter Verdyck, Greta Verheyen, H. Van de Velde, Karen Sermon, Claudia Spits
The paper investigates the cellular consequences of aneuploidy in human blastocysts, finding p53-mediated apoptosis and impaired lineage segregation.
eLife · Dec 9, 2024Peer-reviewedDevelopmental Biology