H. Van de Velde

This study shows that SWI/SNF chromatin remodellers are critical for lineage specification in human embryos and blastoids by regulating enhancer accessibility and transcription factor binding.

The frequency of menstrual cycles with a suboptimal decidual reaction determines the recurrence risk of miscarriage.

The paper investigates the cellular consequences of aneuploidy in human blastocysts, finding p53-mediated apoptosis and impaired lineage segregation.

The paper investigates the role of YAP1 and TEAD1 in lineage segregation during human pre-implantation embryos, showing their involvement in trophectoderm and primitive endoderm formation independent of polarity.

The paper identifies mtDNA variants in ART and spontaneously conceived individuals linked to lower birth weight, showing sex-dependent effects and maternal aging influences.

The paper investigates the conservation of Hippo signaling in the first lineage specification event across four mammalian species, finding that inhibiting the Hippo pathway drives ectopic trophectoderm initiation in all species.

The paper shows that mtDNA mosaicism arises early in human preimplantation development and persists into adulthood through asymmetric mitochondrial distribution.