Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution
Grant E. Duclos, VITOR HUGO TEIXEIRA, Patrick Autissier, Yaron B. Gesthalter, Marjan Reinders-Luinge, Robert Terrano, Yves M. Dumas, Gang Liu, Sarah A. Mazzilli, Corry‐Anke Brandsma, Maarten van den Berge, Sam M. Janes, Wim Timens, Marc E. Lenburg, Avrum E. Spira, , Jennifer Beane
This study uses single-cell RNA sequencing to analyze smoking effects on bronchial epithelial cell types, identifying molecular changes and a novel subpopulation linked to premalignant lesions.
Science Advances · Dec 6, 2019Peer-reviewedGenomics