Patrick Autissier

The increased production of monocytes with immunosuppressive transcriptional profiles predicts the development of SIV encephalitis

The study identifies immunosuppressive monocytes predicting SIV encephalitis by analyzing their transcriptional changes during infection.

Resolving Inflammation: The Impact of Antiretroviral Therapy on Macrophage Traffic In and Out of the CNS.

This study examines how antiretroviral therapy (ART) affects macrophage movement in and out of the CNS in SIV-infected macaques, showing ART reduces perivascular macrophage accumulation but not meningeal or choroid plexus macrophages.

CRISPR-Hybrid: A CRISPR-Mediated Intracellular Directed Evolution Platform for RNA Aptamers

This paper introduces a CRISPR-mediated platform for intracellular directed evolution of RNA aptamers, identifying novel orthogonal aptamer-RBP pairs for multiplexed gene regulation.

Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution

This study uses single-cell RNA sequencing to analyze smoking effects on bronchial epithelial cell types, identifying molecular changes and a novel subpopulation linked to premalignant lesions.

Monocyte Infection Dynamics Shape HIV-1 Phyloanatomy in the Peripheral Blood

This study shows that HIV-1 evolves differently in monocytes compared to T cells, suggesting monocytes may be a significant viral reservoir.