Marc E. Lenburg

This study identifies four molecular archetypes of lung adenocarcinoma premalignant lesions using bulk RNA and exome sequencing, linking proliferation-associated features to aggressive tumor outcomes.

This study validates a bronchial gene expression signature of bronchiectasis in nasal epithelium, showing similar gene expression changes in both tissues.

This study identifies hsa-miR-149-5p as a regulator of immune evasion in progressive bronchial premalignant lesions through integrative analysis of RNA and miRNA sequencing data.

The paper identifies miRNAs and isomiRs associated with COPD and ILD through integrative network analysis of RNA-seq and SNP data from lung tissue samples.

The paper introduces a method to analyze differential miRNA regulation across multiple groups, identifying context-specific targets in immune cells and cancer subtypes.

The paper examines heteroplasmic mitochondrial genetic variants in human cardiac tissues and finds they differ from those in blood and skeletal muscle, with higher variant counts in cardiac tissue linked to age.

This study uses single-cell RNA sequencing to analyze smoking effects on bronchial epithelial cell types, identifying molecular changes and a novel subpopulation linked to premalignant lesions.