The molecular determinants of R-roscovitine block of hERG channels
B. D. Cernuda, C. D. Fernandes, S. Allam, M. Orzillo, G. Suppa, Z. Chia Chang, D. Athanasopoulos, Z. Buraei
This study investigates how R-roscovitine inhibits hERG channels by analyzing mutations and IC50 values, suggesting some residues are critical while others are not, with implications for drug screening and CiPA guidelines.
bioRxiv · May 21, 2019Pharmacology & Toxicology