Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif
A. Brkic, M. Leibundgut, J. Jablonska, V. Zanki, Z. Car, V. Petrovic-Perokovic, A. Marsavelski, N. Ban, I. Gruic-Sovulj
The paper identifies a structural basis for mupirocin resistance in IleRS2, showing that an altered HIGH motif leads to hyper-resistance.
bioRxiv · Jan 31, 2023Biochemistry