Mammalian Cell Proliferation Requires Noncatalytic Functions of O-GlcNAc Transferase
Z. G. Levine, S. C. Potter, C. M. Joiner, G. Q. Fei, B. Nabet, M. Sonnett, N. E. Zachara, J. A. Paulo, S. Walker
This paper shows that OGT's noncatalytic functions are essential for cell proliferation, while its glycosyltransferase activity is sufficient for viability.
bioRxiv · Oct 22, 2020Biochemistry