Author

N. E. Zachara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

C. Slawson· 2 shared D. R. Robarts· 2 shared J. A. Hanover· 2 shared M. Kotulkar· 2 shared U. Apte· 2 shared B. Nabet· 1 shared C. M. Joiner· 1 shared D. Paine-Cabrera· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersPathology

C. Slawson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The Essential Role of O-GlcNAcylation in Hepatic Differentiation

D. R. Robarts, M. Kotulkar, D. Paine-Cabrera, K. K. Venneman, J. A. Hanover, N. E. Zachara, C. Slawson, U. Apte

This study shows that O-GlcNAcylation is essential for hepatocyte differentiation and its loss promotes liver fibrosis and hepatocellular carcinoma.

bioRxiv · Feb 16, 2023Pathology

Regulation of Liver Regeneration by hepatocyte O-GlcNAcylation in mice

D. R. Robarts, S. R. McGreal, D. S. Umbaugh, W. S. Parkes, M. Kotulkar, S. Abernathy, N. Lee, H. Jaeschke, S. Gunewardena, S. A. Whelan, J. A. Hanover, N. E. Zachara, C. Slawson, U. Apte

This study shows that O-GlcNAcylation in hepatocytes is essential for proper liver regeneration, with its loss leading to uncontrolled proliferation and tumor formation.

bioRxiv · Oct 14, 2021Pathology

Mammalian Cell Proliferation Requires Noncatalytic Functions of O-GlcNAc Transferase

Z. G. Levine, S. C. Potter, C. M. Joiner, G. Q. Fei, B. Nabet, M. Sonnett, N. E. Zachara, J. A. Paulo, S. Walker

This paper shows that OGT's noncatalytic functions are essential for cell proliferation, while its glycosyltransferase activity is sufficient for viability.

bioRxiv · Oct 22, 2020Biochemistry