Author

B. Nabet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

N. S. Gray· 2 shared A. L. Leggett· 1 shared A. Munkacsi· 1 shared A. Robichaud· 1 shared A. S. Conway· 1 shared A. Yang· 1 shared A. Zijlstra· 1 shared B. J. Pinch· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

N. S. Gray

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Automated tumor immunophenotyping predicts clinical benefit from anti-PD-L1 immunotherapy

X. Li, J. Eastham, J. M. Giltnane, W. Zou, A. Zijlstra, E. Tabatsky, R. Banchereau, C.-W. Chang, B. Nabet, N. Patil, L. Molinero, S. Chui, M. Peterson, S. Lau, L. Rangell, , H. Koeppen

This paper develops automated tumor immunophenotyping pipelines to predict clinical benefit from anti-PD-L1 therapy in NSCLC and TNBC patients.

bioRxiv · Apr 3, 2023Pathology

Chemical degradation of BTK/TEC as a novel approach to inhibit platelet function and thrombosis.

J. S. Trory, A. Munkacsi, K. Sledz, L. J. Goudswaard, K. J. Heesom, S. F. Moore, B. Nabet, V. K. Aggarwal, I. Hers

This study shows that chemical degradation of BTK/TEC in human platelets reduces thrombotic function without affecting PAR-1-mediated responses.

bioRxiv · May 30, 2022 · PreprintCell Biology

Mammalian Cell Proliferation Requires Noncatalytic Functions of O-GlcNAc Transferase

Z. G. Levine, S. C. Potter, C. M. Joiner, G. Q. Fei, B. Nabet, M. Sonnett, N. E. Zachara, J. A. Paulo, S. Walker

This paper shows that OGT's noncatalytic functions are essential for cell proliferation, while its glycosyltransferase activity is sufficient for viability.

bioRxiv · Oct 22, 2020Biochemistry

Sulfopin, a selective covalent inhibitor of Pin1, blocks Myc-driven tumor initiation and growth in vivo

C. Dubiella, B. J. Pinch, D. Zaidman, T. D. Manz, E. Poon, S. He, E. Resnick, E. M. Langer, C. J. Daniel, H.-S. Seo, Y. Chen, S. B. Ficarro, Y. Jamin, X. Lian, S. Kibe, , N. London

Sulfopin, a selective Pin1 inhibitor, reduces tumor initiation and growth in neuroblastoma models by targeting c-Myc pathways.

bioRxiv · Mar 20, 2020 · PreprintCancer Biology

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

B. Nabet, F. M. Ferguson, B. K. A. Seong, M. Kuljanin, A. L. Leggett, M. L. Mohardt, A. Robichaud, A. S. Conway, D. L. Buckley, J. D. Mancias, J. E. Bradner, K. Stegmaier, N. S. Gray

This paper introduces dTAGV-1, a VHL-recruiting dTAG molecule that rapidly degrades FKBP12F36V-tagged proteins, overcoming limitations of CRBN-recruiting dTAGs and enabling combination degrader studies in cells and mice.

bioRxiv · Mar 13, 2020Cancer Biology