Experimental and mathematical insights on the interactions between poliovirus and a defective interfering genome
R. Andino, Y. Shirogane, E. Rousseau, J. Voznica, Y. Xiao, W. Su, A. Catching, Z. J. Whitfiled, I. M. Rouzine, S. Bianco
The paper investigates how defective interfering genomes affect wild-type poliovirus replication using a mathematical model and experimental data, finding that DI replication and encapsidation are key factors in determining viral competition outcomes.
bioRxiv · Jan 11, 2021Microbiology