Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels
B. Teng, J. Kaplan, Z. Liang, Z. Krieger, Y.-H. Tu, B. Burendei, A. B. Ward, E. Liman
This study identifies structural motifs in OTOP channels that determine subtype-specific pH sensitivity, showing that proton gating is mediated by extracellular linkers in the N and C domains.
bioRxiv · Mar 1, 2022Biophysics