Z. Liang

π-SPECFormer: A Mass Spectrometry-based Foundation Model for Decoding the Dark Proteome

This paper introduces π-SPECFormer, a foundation model for mass spectrometry-based proteomics that decodes the dark proteome by pre-training on unannotated spectra and outperforms baselines in peptide sequencing and modification detection.

Synergistic Multi-Enzyme Cascades Assembled on Modular Protein Scaffolds for Efficient PET Biorecycling

This paper develops a modular protein scaffold system to assemble multiple enzymes for efficient PET biorecycling, achieving higher conversion rates than previous systems.

A beta-Galactosidase acting on unique galactosides: the structure and function of a beta-1,2-galactosidase from Bacteroides xylanisolvens, an intestinal bacterium

This study identifies a beta-galactosidase from Bacteroides xylanisolvens that hydrolyzes beta-1,2-galactooligosaccharides, revealing its unique substrate specificity through structural and biochemical analysis.

Chemotherapy induces myeloid-driven spatial T-cell exhaustion in ovarian cancer

This study shows chemotherapy causes myeloid-driven spatial T-cell exhaustion in ovarian cancer by altering immune cell states and interactions, suggesting new immunotherapy approaches.

A hemagglutinin and neuraminidase biased immunological memory shapes the dynamics of antibody responses to Influenza A virus

The paper shows that pre-existing immunity to specific influenza antigens biases post-infection antibody responses, altering their dynamics and breadth.

A multi-modal image fusion workflow incorporating MALDI imaging mass spectrometry and microscopy for the study of small pharmaceutical compounds

This paper presents a multi-modal image fusion workflow combining MALDI imaging mass spectrometry with microscopy to improve spatial resolution and co-registration of pharmaceutical compound and receptor data.

Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer

This study develops and tests EREG-targeting ADCs showing efficacy in both RAS mutant and wildtype CRC, with high potency and safety in preclinical models.

Hist2Cell: Deciphering Fine-grained Cellular Architectures from Histology Images

Hist2Cell predicts fine-grained transcriptional cell types from histology images with high accuracy, enabling cellular mapping and cancer prognosis.

Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction and leads to increased glucose uptake in tafazzin-deficient cells

This study identifies the upregulation of the AMPK-FOXO1-PDK4 pathway as the mechanism causing reduced PDH activity and increased glucose uptake in tafazzin-deficient cells.

Chromosome segment scanning for gain- or loss-of-function screening (CHASING) and its application in metabolic engineering

The paper introduces CHASING, a method for gain- or loss-of-function screening using chromosome-segment deletions, and applies it to identify metabolic engineering targets in B. subtilis.

Auditory High Entropy Response (A-HER): A Novel Paradigm for Studying Brain Processing of Uncertain Information

The paper introduces A-HER, a paradigm that maximizes auditory stimulus entropy to study brain processing of uncertain information, showing improved signal-to-noise ratio and repeatability compared to other methods.

The Effects of Different Fatigue Types on Action Anticipation and Physical Performance in High-level Volleyball Players

This study investigates how different fatigue types affect action anticipation and physical performance in volleyball players, finding that dual fatigue has the most significant negative impact.

High-throughput and in-depth analysis of plasma proteome by UV-assisted protein digestion, 5-plex labeling and MS-based high abundance protein removal method

This study develops a high-throughput plasma proteome analysis workflow using UV-assisted digestion, 5-plex labeling, and MS-based high abundance protein removal to improve quantification of low-abundance proteins.

Proximity proteomics reveals UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia

The paper identifies UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia through proximity proteomics and functional assays.

Instant Assembly of Collagen for Scaffolding, Tissue Engineering, and Bioprinting

This paper introduces TRACE, a method for instant collagen gelation and patterning, enabling applications in biofabrication and tissue engineering.

Nitric Oxide controls shoot meristem activity via regulation of DNA methylation

This study shows that nitric oxide regulates DNA methylation in Arabidopsis shoot meristems by modulating AGO4 activity and its interaction with the WUSCHEL transcription factor.

Single-cell impedance cytometry of anticancer drug-treated tumor cells exhibiting mitotic arrest state to apoptosis using low-cost silver-PDMS microelectrodes

This study uses microfluidic impedance cytometry to analyze the cellular state changes in Hela cells treated with paclitaxel and vinblastine, showing distinct electrical parameter shifts during mitotic arrest and apoptosis.

Group A Streptococcus remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination

This study shows Group A Streptococcus remains viable inside fibrin clots and accesses plasminogen to dissolve clots and disseminate, with faster dissolution when plasminogen is pre-bound to the bacteria.

CD4+ T cell senescence is associated with reduced reactogenicity in severe/critical COVID-19

The paper finds that higher levels of CD4+ T cell senescence in severe/critical COVID-19 patients correlate with reduced antibody responses and worse survival, especially in breakthrough infections.

SWI/SNF chromatin remodeling determines brassinosteroid-induced transcriptional activation

This study shows that SWI/SNF chromatin remodeling is required for BZR1-mediated transcriptional activation in Arabidopsis thaliana.

Contribution of the IGCR1 regulatory element and the 3'Igh CBEs to Regulation of Igh V(D)J Recombination

This study investigates how IGCR1 regulatory elements and 3'Igh CBEs influence RAG-scanning and V(D)J recombination in progenitor-B cells through chromatin loop extrusion and WAPL down-regulation.

Zn2+ potentiation of OTOP proton channels identifies structural elements of the gating apparatus

This paper identifies structural elements in the OTOP channel family that mediate Zn2+ activation, revealing the tm 11-12 linker as part of the gating apparatus.

A hierarchical strategy to decipher protein dynamics in vivo with chemical cross-linking mass spectrometry

This paper introduces a hierarchical strategy using CXMS and AlphaFold2 to analyze protein dynamics in vivo, focusing on IDPs and multi-domain proteins.

Membrane and glycocalyx tethering of DNA nanostructures for enhanced uptake

This study enhances DNA nanostructure cellular uptake by targeting membrane and glycocalyx, showing improved uptake and endocytic pathways involving scavenger receptors and clathrin/caveolin mechanisms.

CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis

This study identifies CRB3's role in navigating Rab11 vesicles to promote γTuRC assembly during ciliogenesis and its regulation of Hh and Wnt signaling in tumorigenesis.

Towards reliable reconstruction of the mouse brain thalamocortical connectivity using diffusion MRI

This study optimizes dMRI tractography for reliable reconstruction of the mouse brain thalamocortical network by evaluating imaging and tractography parameters using an atlas and tracer data.

Organization, genomic targeting and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis

Flow-induced mechanical coupling between perinuclear actin cap and nucleus governs spatiotemporal regulation of YAP transport

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

Targeted genome editing in grape using multiple CRISPR-guided editing systems

This study evaluates CRISPR/Cas9, CRISPR/LbCpf1, and base editors for targeted genome editing in grape, showing variable efficiencies and PAM specificity.

CRISPR Screens Identify Novel Regulators of cFLIP Dependency and Ligand-Independent, TRAIL-R1-Mediated Cell Death

The paper identifies novel regulators of cFLIP dependency and ligand-independent TRAIL-R1-mediated cell death in PEL cells using CRISPR screens and functional experiments.