Tumor suppressor p53 deficiency increases tumor immunogenicity through promoting IL33-mediated anti-tumor immune responses
Y. Li, D. S. Gao, L. Yi, F. Gao, R. Sun, K. K. Lu, J. Xu, J. Shoush, Z. Kykrou, M. Liang, B. Lu
This study shows that p53 deficiency in tumors enhances immunogenicity by increasing IL-33, which improves response to PD-1 ICB therapy in a mouse model.
bioRxiv · Sep 11, 2022 · PreprintImmunology