M. Liang

Inhibition of Endothelial Lipase by MEDI5884 Normalizes Phosphatidylinositol Levels in Coronary Artery Disease Patients

This study shows that MEDI5884 increases phosphatidylinositol levels in CAD patients by inhibiting endothelial lipase, correlating with improved HDL function and reverse cholesterol transport.

Ferroptosis mediates the progression of hyperuricemic nephropathy by activating RAGE signaling

This study shows ferroptosis contributes to hyperuricemic nephropathy by activating RAGE signaling, and inhibiting ferroptosis improves renal injury and fibrosis in a mouse model.

Atomic resolution map of the solvent interactions driving SOD1 unfolding in CAPRIN1 condensates

This study uses NMR to show CAPRIN1 condensates shift SOD1 folding towards unfolded states, promoting aggregation, while a zinc-bound dimeric form is more stable.

Identification and classification of the genomes of novel Microviruses in a poultry slaughterhouse

This study identifies 98 novel microvirus genomes from a poultry slaughterhouse, classifies them into 6 new subfamilies and 3 higher-level units, and expands their known host range.

4D Crystallography Captures Transient IF1-Ribosome Dynamics in Translation Initiation

This study uses 4D crystallography to capture transient dynamics of IF1 binding to the 30S ribosomal subunit, revealing allostery and interactions during translation initiation.

Ambient Temperature Bacterial Large Ribosomal Subunit Structure Enabled by Serial Femtosecond X-ray Crystallography

This study determines the structure of the 50S ribosomal subunit from Thermus thermophilus at ambient temperature using serial femtosecond X-ray crystallography, revealing new dynamics and antibiotic binding sites.

Development of peptides for targeting cell ablation agents concurrently to the Sertoli and Leydig cell populations of the testes: an approach to non-surgical sterilization

This study develops peptides to target and ablate Sertoli and Leydig cells in testes, aiming to create a non-surgical sterilization method for cats and dogs.

Metabolic responses of normal rat kidneys to a high salt intake.

This study examines how normal rat kidneys respond metabolically to a high salt diet, showing increased glycolysis and oxygen consumption despite reduced TCA cycle enzyme expression.

Tumor suppressor p53 deficiency increases tumor immunogenicity through promoting IL33-mediated anti-tumor immune responses

This study shows that p53 deficiency in tumors enhances immunogenicity by increasing IL-33, which improves response to PD-1 ICB therapy in a mouse model.

Rational control of structural off-state heterogeneity in a photoswitchable fluorescent protein provides switching contrast enhancement

This paper enhances switching contrast in photoswitchable fluorescent proteins by modifying the V151 side chain, improving performance in RESOLFT nanoscopy.

Desiccation resistance differences in Drosophila species can be largely explained by variations in cuticular hydrocarbons

This study shows that variations in cuticular hydrocarbons, particularly methyl-branched CHCs, largely explain desiccation resistance differences among Drosophila species.

Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

A novel intranasal administration adenoviral vector-based platform for rapid COVID-19 vaccine development

This paper develops a chimpanzee adenovirus-based vaccine against the SARS-CoV-2 Delta variant and shows it induces strong immunity and protects mice from challenge.

Cooperative Allostery and Structural Dynamics of Streptavidin at Cryogenic- and Ambient-temperature

The paper presents two apo-streptavidin structures at different temperatures and reveals cooperative allostery through water-mediated interactions.

Antibody Cocktail Exhibits Broad Neutralization against SARS-CoV-2 and SARS-CoV-2 variants

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

Structural insight into host plasma membrane association and assembly of HIV-1 Matrix protein

This study presents crystal structures of HIV-1 MA domain bound to IP6, revealing its binding mode and interaction with PIP2, providing insights into virion assembly.

Near-Physiological-Temperature Serial Femtosecond X-ray Crystallography Reveals Novel Conformations of SARS-CoV-2 Main Protease Active Site for Improved Drug Repurposing

The paper determines two apo structures of SARS-CoV-2 main protease at near-physiological temperature using SFX and uses molecular simulations to analyze inhibitor binding for drug repurposing.

Lipidomic profiling of plasma extracellular vesicles as an effective means to evaluate the risk of preterm birth

This study identifies lipid differences in plasma, microvesicles, and exosomes between preterm and full-term pregnancies, finding microvesicle lipids better predict preterm birth risk.

Genetic diversity and evolution of Hantaan virus in China and its neighbors

This study analyzes HTNV genetic diversity and evolution in China and neighboring regions, identifying phylogroups, recombination events, and geographic clustering patterns.

Ferroptosis contributes to developmental cell death in rice blast

This study identifies ferroptosis as a key developmental cell death mechanism in the rice blast fungus, showing its role in pathogenic growth and host invasion.

Serial femtosecond X-ray diffraction of HIV-1 Gag MA-IP6 microcrystals at ambient temperature

This study uses serial femtosecond X-ray crystallography to analyze HIV-1 Gag MA-IP6 microcrystals at ambient temperature, achieving high-resolution diffraction data.

Aminoglycoside ribosome interactions reveal novel conformational states at ambient temperature

This study examines aminoglycoside interactions with the bacterial 30S ribosome at ambient and cryogenic temperatures, revealing temperature-sensitive conformational changes and new structural states.

Structure of the 30S ribosomal decoding complex at ambient temperature

The paper reports an ambient-temperature X-ray crystal structure of the Thermus thermophilus 30S ribosomal decoding complex, showing consistency with cryogenic structures but with minor conformational variations.

Enzyme Intermediates Captured "on-the-fly" by Mix-and-Inject Serial Crystallography

This paper demonstrates a method to capture enzyme reactions in real-time using mix-and-inject serial crystallography, revealing antibiotic cleavage and kinetic transitions in Mycobacterium tuberculosis β-lactamase.

Candidate cancer driver mutations in super-enhancers and long-range chromatin interaction networks

The paper identifies 41 frequently mutated regulatory elements in cancer genomes, enriched in non-coding mutations and linked to gene expression control through chromatin interactions.