Glomerulosclerosis and kidney failure in a mouse model of monoclonal immunoglobulin light-chain deposition disease
S. Bender, M. V. Ayala, A. Bonaud, V. Javaugue, C. Carrion, C. Oblet, A. Rinsant, N. Quellard, S. Kaaki, Z. Oruc, F. Boyer, A. Paquet, N. Pons, B. Herve, M. O. Ashi, , C. Sirac
This study develops a mouse model of light chain deposition disease, showing that pathogenic light chains cause glomerulosclerosis and kidney failure, and identifies potential therapeutic targets.
bioRxiv · May 2, 2019 · PreprintPathology