M. O. Ashi

Uncoupling splicing from transcription using antisense oligonucleotides reveals a dual role for I exon donor splice sites in antibody class switching

This study uses antisense oligonucleotides to show that I exon donor splice sites are essential for both transcriptional regulation and splicing during antibody class switching.

Glomerulosclerosis and kidney failure in a mouse model of monoclonal immunoglobulin light-chain deposition disease

This study develops a mouse model of light chain deposition disease, showing that pathogenic light chains cause glomerulosclerosis and kidney failure, and identifies potential therapeutic targets.