CEACAM5/6+ Tumor Cells and IL-1β+ Macrophages Drive Resistance to Chemo-immunotherapy in Gastric Cancer
Jian Chen, Liudeng Zhang, Yikai Luo, Xu Han, Muxing Kang, Jing Chen, Wei Liu, Zhenzhen Xun, Guofeng Chen, Ke Chen, Shenbin Xu, Yu Zhang, Zhiwei Wu, Wenxuan Wu, Z. R. Hao, , Han Liang
The paper identifies two resistance mechanisms in gastric cancer to chemo-immunotherapy, involving CEACAM5/6+ tumor cells and IL-1β+ macrophages, and suggests them as biomarkers and therapeutic targets.
bioRxiv · Mar 8, 2026 · PreprintCancer Biology