Ke Chen

The paper identifies a novel Cas12a variant, BvCas12a, with high specificity and engineers variants with broader PAM compatibility and improved editing efficiency.

The paper identifies two resistance mechanisms in gastric cancer to chemo-immunotherapy, involving CEACAM5/6+ tumor cells and IL-1β+ macrophages, and suggests them as biomarkers and therapeutic targets.

This study identifies NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages as drivers of chemoradiotherapy resistance in ESCC through multi-omics analysis of clinical trial data.

This study evaluates ICD-related genes in bladder cancer to assess prognosis and immunotherapy response, finding higher ICD expression correlates with better survival and response to PD1-targeted therapy.

This study introduces STAMP, a novel method for genetic perturbation outcome prediction that improves accuracy across three subtasks and provides a benchmarking framework for evaluating models.