Xu Han

The paper identifies two resistance mechanisms in gastric cancer to chemo-immunotherapy, involving CEACAM5/6+ tumor cells and IL-1β+ macrophages, and suggests them as biomarkers and therapeutic targets.

This study shows that Cullin3 enhances aPKC activity to localize Numb at the basal cortex, promoting differentiation of Drosophila neural stem cell progeny by downregulating Notch signaling.