Author

Guofeng Chen

Chinese Academy of SciencesORCID 0000-0003-1927-088XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Haixia SuiD· 1 shared Han LiangiD· 1 shared Hangchen HuiD· 1 shared Jian Chen· 1 shared Jing Chen· 1 shared Ke CheniD· 1 shared Lie WangiD· 1 shared Liudeng ZhangiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Haixia SuORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMar 8, 2026

CEACAM5/6+ Tumor Cells and IL-1β+ Macrophages Drive Resistance to Chemo-immunotherapy in Gastric Cancer

Jian Chen, Liudeng Zhang, Yikai Luo…·Han Liang

The paper identifies two resistance mechanisms in gastric cancer to chemo-immunotherapy, involving CEACAM5/6+ tumor cells and IL-1β+ macrophages, and suggests them as biomarkers and therapeutic targets.

DOI 10.64898/2026.03.05.708917

humanscRNA-seq

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Molecular BiologybioRxivPreprintMar 30, 2022

Identification of C270 as a novel site for allosteric modulators of SARS-CoV-2 papain-like protease

Hangchen Hu, Qian Wang, Haixia Su…·Yechun Xu

The paper identifies C270 as a novel allosteric site for modulators of SARS-CoV-2 PLpro, revealing a mechanism for covalent activation and inhibition.

1 citation

experimental assay

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