Splicing inhibition enhances the antitumor immune response through increased tumor antigen presentation and altered MHC-I immunopeptidome
Alison Pierson, Romain Darrigrand, Marine Rouillon, Mathilde Boulpicante, Zafiarisoa Dolor Renko, Camille Garcia, Michael Ghosh, Marie-Charlotte Laiguillon, Camille Lobry, Mouad Alami, Sébastien Apcher
This study shows that splicing inhibition with IP2 enhances antitumor immunity by increasing antigen presentation and altering MHC-I immunopeptidomes.
bioRxiv · Jan 6, 2019 · PreprintImmunology