Loss of ovarian function and estrogen therapy remodel the brain's synaptic and metabolic proteome
Sebastian F. Salathe, Edziu Franczak, Zane Busick, Frederick B. Boakye, Julie Allen, Andrew J. Lutkewitte, Heather Wilkins, John P. Thyfault, Benjamin A. Kugler
This study shows that estrogen therapy restores synaptic and metabolic proteins in the brain of aged mice after ovariectomy, improving mitochondrial function and synaptic integrity.
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · Apr 2, 2026Peer-reviewedNeuroscience