Edziu Franczak

Neuronal ketone body utilization couples exercise and time-restricted feeding to cognitive enhancement

This study investigates the role of neuronal and hepatic ketone metabolism in cognitive enhancement from exercise and time-restricted feeding in mice, finding neuronal utilization is essential while hepatic production is contributory.

The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the mouse heart

This study shows trametinib causes mitochondrial injury and innate immune activation in mouse hearts, leading to cardiomyopathy and heart failure.

Hepatic ketogenic insufficiency blunts exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle.

This study shows that liver-specific HMGCS2 knockout reduces exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle.

Loss of ovarian function and estrogen therapy remodel the brain's synaptic and metabolic proteome

This study shows that estrogen therapy restores synaptic and metabolic proteins in the brain of aged mice after ovariectomy, improving mitochondrial function and synaptic integrity.

Hepatocyte Estrogen Receptor α Mediates Estrogen-induced Augmentation of Hepatic 1 Mitochondrial Respiration Following Ovariectomy.

This study shows that estrogen receptor α in hepatocytes is necessary for estrogen to enhance mitochondrial respiration and reduce steatosis after ovariectomy.

APOE4 drives widespread changes to the hepatic proteome and alters metabolic function

In 4-month-old APOE targeted-replacement mice, APOE4 remodels the liver proteome sex-dependently; in isogenic iPSC-derived hepatocytes it impairs respiration and raises glycolysis and lipid droplets.

Adipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice

This study shows that overexpressing NAMPT in adipocytes protects against metabolic dysfunction in male obese mice but not females, via improved interorgan communication and extracellular vesicle effects.

Proteomic and metabolic profiling reveals APOE4-dependent shifts in whole brain, neuronal, and astrocytic mitochondrial function and glycolysis

This study identifies APOE4-dependent metabolic changes in brain cells, showing increased glycolysis and mitochondrial dysfunction in neurons and astrocytes.

Endurance exercise drives temporal and sexual dimorphic multi-omic adaptations in liver metabolism-Findings from MoTrPAC.

This study examines how endurance exercise affects liver metabolism in male and female rats over time, revealing sex-specific molecular changes and protective effects.

Aerobic capacity and exercise mediate protection against hepatic steatosis via enhanced bile acid metabolism.

The paper shows aerobic capacity and exercise enhance bile acid metabolism, which is critical for reducing hepatic steatosis in mice.