Benjamin A. Kugler

This study investigates the role of neuronal and hepatic ketone metabolism in cognitive enhancement from exercise and time-restricted feeding in mice, finding neuronal utilization is essential while hepatic production is contributory.

This study shows that estrogen therapy restores synaptic and metabolic proteins in the brain of aged mice after ovariectomy, improving mitochondrial function and synaptic integrity.

This study shows that estrogen receptor α in hepatocytes is necessary for estrogen to enhance mitochondrial respiration and reduce steatosis after ovariectomy.

This study shows that voluntary exercise reduces tumor growth in a mouse model of castration-resistant prostate cancer by affecting DNA replication, AR signaling, and mitochondrial dynamics.

The paper shows aerobic capacity and exercise enhance bile acid metabolism, which is critical for reducing hepatic steatosis in mice.