Genomic and Transcriptomic Signatures of SETD1A Disruption in Human Excitatory Neuron Development and Psychiatric Disease Risk
Zhixiong Sun, Huixiang Zhu, Xiaofu He, Bas Lendemeijer, Zanxu Wang, Jack Fan, Yan Sun, Zhiguo Zhang, Sander Markx, Steven A. Kushner, Bin Xu, Joseph A. Gogos
This study investigates how SETD1A disruption affects gene regulation and neurodevelopment, linking it to schizophrenia risk through chromatin and transcriptomic analyses in human organoids.
bioRxiv · Mar 26, 2025 · PreprintNeuroscience